The latter was examined in detail due to the prevalence of HOO˙ as a source of oxidative stress in biological systems. The results show that FX has moderate activity in the aqueous physiological environment against a range of radicals including HO˙, CCl 3O˙, CCl 3OO˙, NO 2,, and HOO˙. In this study, we report on a systematic evaluation of the radical scavenging activity of FX using a two-tier protocol based on thermodynamic and kinetic calculations. This compound was shown to protect endothelial cells from oxidative stress however, the nature of its antioxidant properties is still ambiguous. Fraxin (FX) (7-hydroxy-6-methoxycoumarin 8-glucoside) is a typical natural product of the coumarin family.
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